Спрей циновит инструкция: ЦИНОВИТ СПРЕЙ ДЛЯ ПРОБЛЕМНОЙ КОЖИ 75МЛ

ЦИНОВИТ ШАМПУНЬ ДЛЯ ЕЖЕДНЕВНОГО ПРИМЕНЕНИЯ ПРОФИЛАКТИЧЕСКИЙ ОТ ПЕРХОТИ 150МЛ

Линия ЦИНОВИТ — линия средств которая поможет обеспечить комплексное поддержание здоровья и привлекательности проблемной кожи, страдающей от шелушения, покраснения и прочих дискомфортных ощущений.

Внешний вид и свойства: густая вязкая жидкость белого цвета, с приятным свежим запахом с нотами зеленого яблока.

Противогрибковые шампуни от перхоти применяются 2-3 раза в неделю.

Для поддержания терапевтического эффекта и деликатного очищения волос между применениями шампуня от перхоти или между курсами лечения рекомендуются специальные шампуни, которые подходят для ежедневного применения.

Чтобы избежать негативных последствий от частого мытья волос, шампунь для ежедневного применения должен иметь особый состав, который позволяет ему эффективно справиться с различными загрязнениями, при этом сохранить здоровье и силу волос.

ЦИНОВИТ шампунь для ежедневного применения профилактический от перхоти:

• Инновационная формула с цинк пиритионом и климбазолом

• Предупреждает образование перхоти

• Нормализует выработку кожного сала

• Мягко очищает волосы и кожу головы

• Улучшает структуру волос, укрепляя и защищая их от воздействия неблагоприятных внешних факторов

• Протестирован дерматолгами

Активные компоненты и область применения:

Инновационная формула ЦИНОВИТ шампуня для ежедневного применения направлена на восстановление баланса микрофлоры волосистой части головы.

Активные компоненты:

-цинк пиритион и климбазол, известные своей антимикробной активностью, способствуют предупреждению образования перхоти и нормализуют выработку кожного сала.

-Д-пантенол улучшает структуру волос, укрепляя и защищая их от воздействия неблагоприятных внешних факторов.

-Мочевина оказывает увлажняющее действие.

Шампунь содержит мягкие ПАВ (поверхностно активные вещества) и имеет нейтральный рН, за счет чего мягко очищает волосы и кожу головы.

ЦИНОВИТ шампунь для ежедневного применения профилактический от перхоти может использоваться:

— самостоятельно в качестве базового средства для ежедневного ухода за волосами и чувствительной кожей головы и для предупреждения образования перхоти;

— в сочетании с шампунями от перхоти (например, ЦИНОВИТ шампунем от перхоти).

Подходит для любого типа волос.

90000 Instructions for Spectracide Malathion Insect Spray Concentrate | Home Guides 90001 90002 By Audrey Lynn Updated December 14, 2018 90003 90002 Since 1956, malathion has been used for insect control and is often used by municipalities to control mosquito populations. The chemical is considered safe for humans and the environment when used under specific conditions and at specific concentrations. Malathion is highly toxic to honeybees, according to the University of California Statewide Integrated Pest Management website, and should only be used in late evening if honeybees are present.Spectracide Malathion Insect Spray Concentrate is the brand name of a liquid pesticide homeowners can use on flowering and fruiting plants as well as some vegetables. 90003 90006 Ornamentals 90007 90002 You can use Spectracide Malathion Insect Spray Concentrate on evergreens, azaleas, camellias, chrysanthemums and roses, but not on petunias. Also do not use the insecticide on crassula species or on Boston, maidenhair or petris ferns. 90003 90002 For aphid control, mix 1.5 to 2 teaspoons of concentrate to each gallon of water and spray on the infested plants.To eliminate bagworms, boxelder bugs, four-lined leaf bugs, adult Japanese beetles, mealybugs, spider or spruce mites, rose leafhoppers, tarnished plant bugs, thrips, whiteflies and woolly aphids, mix 1 tablespoon to each gallon of water. Control oak kermes and juniper or etcher scales with a mixture of 2 teaspoons per gallon of water, while spraying scale insects with a mixture of 1.5 to 2 tablespoons of concentrate per gallon of water. 90003 90012 Fruits 90007 90002 Spray apricots twice a year, with at least a one-week interval between sprays and no fewer than six days before harvest.You may spray cherries four times per year, but not within three days of harvest. Do not spray grapes within three days of harvest, but you may spray them up to twice a year at no less than two-week intervals. 90003 90002 You may spray peaches up to a week before harvest. Spray up to three times yearly at no less than 11-day intervals. Do not spray strawberries within three days of harvest. However, you can spray them up to four times annually, with at least a week between sprays. 90003 90002 Control aphids with a mix of 1.5 to 2 teaspoons of pesticide concentrate to each gallon of water. Control leafhoppers, leafrollers, moths, mites, caterpillars, whiteflies, woolly aphids, psyllids and plum curculio with a mixture of 1 tablespoon of concentrate to each gallon of water. Spray scale crawlers with a mixture of 1.5 to 2 tablespoons of concentrate per gallon of water. 90003 90002 Do not spray citrus trees during bloom or within one week of harvest, but you can treat them three times per year otherwise. Spray at intervals of at least 30 days apart.Control aphids, scale insects, thrips and whiteflies on citrus by spraying with a mixture of 2 teaspoons of concentrate to each gallon of water. 90003 90022 Vegetables 90007 90002 To control aphids on vegetable plants, mix 1.5 to 2 teaspoons into each gallon of water and spray the infested plants. Mix 1 tablespoon of concentrate into each gallon of water to control whiteflies, adult Japanese beetles, bean or potato leafhoppers, red spider mites, thrips, mealybugs and tarnished plant bugs as well as four-lined leaf bugs and leafhoppers.You can spray beans, broccoli, Brussels sprouts and cauliflower twice yearly with at least a week between applications. Do not apply to beans within one day of harvest, or the other vegetables within two days of harvest. 90003 90002 Spray lettuce twice yearly, with at least six days between sprays and not within two weeks of harvest. You may spray kale, squash and radishes three times a year with at least a week between sprays. Do not spray squash within one day of harvest and do not spray kale or radishes within a week of harvest.90003 90002 You can spray peas and potatoes twice yearly with at least a one-week interval in between. Do not spray peas within three days of harvest. You can spray potatoes until harvest. Do not spray tomatoes within one day of harvest, but you can spray them up to four times annually with at least five days between applications. 90003 90030 Spraying Instructions 90007 90002 Spray plants thoroughly to cover all parts of the plants including the undersides of leaves. Begin spraying when you discover insects on the plants.You may need to agitate the mixture occasionally in the sprayer to keep it properly mixed. Avoid spraying when people or pets are in the vicinity, or on windy days. 90003.90000 How to Use Nasal Spray 90001 90002 Many medications can be given into the nose with nasal spray. Most of these medications treat problems within the nose and sinus area, such as nasal congestion. Nasal sprays are available as over-the-counter or prescription drugs. 90003 90002 Nasal spray comes in two forms: a regular spray and a pump spray. It’s important to use these products correctly. This makes sure they deliver the medication properly so your body can absorb it. 90003 90002 In addition to your nasal spray, you’ll need soap and water or hand sanitizer to clean your hands.You’ll also need some tissues to blow your nose before using the nasal spray. 90003 90002 You can use these instructions for using nasal spray yourself. If you’re a parent or caregiver, you can also use these steps to give nasal spray to a child or another adult. 90003 90002 90011 Preparing 90012 90003 90014 90015 Gather your supplies. These include the nasal spray or nasal pump spray plus tissues. 90016 90015 Gently blow your nose to clear your nasal passages. 90016 90015 Wash your hands with soap and water and then dry them with a clean towel or paper towel.If soap and water are not available, use hand sanitizer instead. 90016 90015 If directed by the product label or by your doctor or pharmacist, shake the nasal spray bottle gently. 90016 90023 90002 90011 Using the spray 90012 90003 90002 The steps are slightly different for the nasal spray and the pump nasal spray. 90003 90002 90011 90032 Using a nasal spray 90033 90012 90003 90014 90015 Close the nostril that is not receiving the medication. Do this by gently pressing on that side of your nose.90016 90015 Gently insert the bottle tip into the other nostril. 90016 90015 Breathe in deeply through that nostril as you squeeze the bottle. Remove the bottle and sniff once or twice. 90016 90015 Repeat if directed. Wait at least 10 seconds between sprays. 90016 90015 If directed, repeat steps 1-4 for the other nostril. 90016 90023 90002 90011 90032 Using a pump nasal spray 90033 90012 90003 90014 90015 Hold the bottle with your index and middle fingers on each side of the bottle and your thumb on the bottom of the bottle.90016 90015 Prime the bottle. This is typically done by spraying the product one or more times into the air or into a tissue. See the product label for specific instructions. 90016 90015 Tilt your head slightly forward. 90016 90015 Close the nostril that is not receiving the medication. Do this by gently pressing on that side of your nose. 90016 90015 Insert the tip of the bottle into the other nostril. 90016 90015 Breathe in deeply through that nostril as you press down on the pump with your index and middle fingers.Remove the bottle and sniff once or twice. Repeat if directed. Wait at least 10 seconds between sprays. 90016 90015 If directed, repeat steps 3-6 for the other nostril. 90016 90023 90002 90011 Finishing up 90012 90003 90014 90015 Put the cap back on the bottle. 90016 90015 Wait a few minutes to blow your nose after using the nasal spray. 90016 90015 Wash your hands to remove any medication. 90016 90015 Store the bottle as directed by the label or by your doctor or pharmacist. 90016 90023 90084 Do’s 90085 90086 90015 90011 Follow the usage instructions from your doctor or the medication label.90012 Use your nasal spray for only as long as recommended, or else it could cause problems. For instance, sprays used to relieve congestion can actually make congestion worse if they’re used for too long. 90016 90015 90011 Talk to your doctor if you develop nosebleeds or irritation in your nose. 90012 Your doctor can help you relieve these problems or they can find a different medication for you. 90016 90095 90084 Don’ts 90085 90086 90015 90011 Do not allow the spray tip to touch anything besides the inside of your nose.90012 If the tip touches any other surface, it could pick up bacteria or other germs that could cause an infection in your nose. 90016 90015 90011 Do not share your nasal spray with anyone else. 90012 Sharing your nasal spray could spread germs or infection. 90016 90095 90002 If you have any problems with your nasal spray, call your doctor. Also call your doctor if: 90003 90086 90015 your condition does not improve after using the spray as directed 90016 90015 you have a nosebleed that does not slow down or stop after 15-20 minutes 90016 90015 you have any questions about using your nasal spray 90016 90095 90002 To help your nasal spray work well, follow these instructions and any directions on the nasal spray label or from your doctor or pharmacist.These steps can help you use your nasal spray easily and safely. 90003 90084 Q: 90085 90002 What conditions are nasal sprays used to treat? 90003 90084 A: 90085 90002 Nasal sprays are often used to treat symptoms of allergies and colds such as congestion, sneezing, and runny nose. But they can be used for other purposes as well. For instance, Tamiflu nasal spray, which contains the drug oseltamivir, can be used to treat the flu. Another nasal spray, which contains the drug calcitonin, can be used to treat osteoporosis in women after menopause.And still another nasal spray, which contains the drug butorphanol, can be used to treat pain. 90003 90128 Healthline Medical Team 90129 90130 Answers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice. 90131.90000 Merlin Pharma Cynovit Injection, 10 * 30ml, Rs 630 / box Sagar Enterprise 90001 Merlin Pharma Cynovit Injection, 10 * 30ml, Rs 630 / box Sagar Enterprise | ID: 6072394597 90002 Product Specification 90003 90004 90005 90006 90007 Packaging Type 90008 90007 Carton Box 90008 90011 90006 90007 Brand 90008 90007 Merlin Pharma 90008 90011 90006 90007 Packaging Size 90008 90007 10 * 30ml 90008 90011 90006 90007 Usage 90008 90007 Clinical, Hospital 90008 90011 90006 90007 Grade Standard 90008 90007 Medicine Grade 90008 90011 90036 90037 90002 Product Description 90003 90040 In order to keep pace with never ending demands of the customers, our company is instrumental in offering 90041 Cynovit Injection.90042 90043 90044 90040 Interested in this product? Get Latest Price from the seller 90044 90040 Contact Seller 90044 90002 Product Image 90003 90040 90052 90002 About the Company 90003 90044 90040 Year of Establishment1981 90044 90040 Legal Status of FirmIndividual — Proprietor 90044 90040 Nature of BusinessWholesaler 90044 90040 Number of Employees26 to 50 People 90044 90040 IndiaMART Member SinceJul 2010 90044 90040 GST27AAFPS8909K1Z1 90044 Established in the year 90041 1981 90042 at 90041 Maharashtra, 90042 We 90041 «Sagar Enterprise» 90042 is a 90041 Sole Proprietorship (Individual) 90042 based firm, engaged as the foremost 90041 Wholesaler, Trader 90042 and 90041 Supplier 90042 of 90041 IP Injection, IP Capsules, IP Tablets, Teething Pills and much more.90042 These products are offered by us most affordable rates. Our products are high in demand due to their premium quality, seamless finish, different patterns and affordable prices. Furthermore, we ensure to timely deliver these products to our clients, through this we have gained a huge client base in the market. Back to Top 90082 1 90082 90040 Have a requirement? 90043 Get Best Price 90044 1 90082 90040 Have a requirement? 90043 Get Best Price 90044 .90000 Desmopressin Nasal Spray — FDA prescribing information, side effects and uses 90001 90002 90003 Generic Name: 90004 desmopressin acetate 90005 90003 Dosage Form: 90004 nasal spray 90005 90009 90002 Medically reviewed by Drugs.com. Last updated on Dec 1, 2019. 90009 90012 Indications and Usage for Desmopressin Nasal Spray 90013 90002 Desmopressin acetate nasal solution (nasal spray) is indicated as antidiuretic replacement therapy in the management of central diabetes insipidus in adults and pediatric patients 4 years of age and older.90009 90002 Limitations of Use: 90009 90002 Desmopressin acetate nasal solution (nasal spray) is not indicated for: 90009 90020 90021 Treatment of nephrogenic diabetes insipidus, 90022 90021 Treatment of primary nocturnal enuresis [see Warnings and Precautions (5.1)], 90022 90021 Use in patients with conditions that compromise the intranasal route of administration (e.g., severe nasal congestion and blockage, nasal mucosa atrophy, severe atrophic rhinitis, recent nasal surgery such as transsphenoidal hypophysectomy) [see Warnings and Precautions (5.2)]. 90022 90021 Use in patients with an impaired level of consciousness, 90022 90021 Use in patients requiring doses less than 10 mcg or doses that are not multiples of 10 mcg [see Dosage Forms and Strengths (3)]. 90022 90031 90012 Desmopressin Nasal Spray Dosage and Administration 90013 90034 Important Administration Instructions 90035 90002 Administer desmopressin acetate nasal solution (nasal spray) by intranasal use only. Instruct patients about appropriate fluid restriction during desmopressin acetate nasal solution (nasal spray) treatment [see Warnings and Precautions (5.1)]. 90009 90002 Must prime the spray pump prior to the first use. Instruct patients to: 90009 90020 90021 Prime pump by pressing down on pump four times (if the spray pump is not used for one week, re-prime the pump by pressing down on the pump once). 90022 90021 Discard desmopressin acetate nasal solution (nasal spray) after 50 sprays since the amount delivered thereafter may be substantially less than the recommended dosage. 90022 90031 90034 Recommended Dosage 90035 90002 The use of desmopressin acetate nasal solution (nasal spray) is not indicated for patients who require less than 10 mcg doses or doses that are not multiples of 10 mcg because the spray pump can only deliver doses of 10 mcg [see Indications and Usage ( 1)].If other doses are required, use another desmopressin acetate product. 90009 90002 Individualize the dosage of desmopressin acetate nasal solution (nasal spray) for each patient with particular attention in pediatric and elderly patients and adjust according to the diurnal pattern of response to limit nocturia and to ensure fluid intake with respect to urine output is not excessive [ see Warnings and Precautions (5.1)]. Monitor continued response to desmopressin acetate nasal solution (nasal spray) by urine volume and osmolality to ensure adequate diuresis to limit the risk of hyponatremia, and include measurements of serum sodium and plasma osmolality as needed.90009 90002 Adults 90009 90002 The recommended dosage in adults is 10 mcg once daily into one nostril up to 40 mcg once daily (or 40 mcg divided into two or three daily doses). If administered more than once a day, adjust for an adequate diurnal rhythm of urine output. 90009 90002 Pediatric Patients 90009 90020 90021 For pediatric patients requiring doses less than 10 mcg, desmopressin acetate nasal solution (nasal spray) is not indicated. 90022 90021 For pediatric patients 4 years of age and older, the recommended starting dosage of desmopressin acetate nasal solution (nasal spray) is 10 mcg once daily into one nostril.The dose can be titrated up to 30 mcg once daily (or 30 mcg divided into two daily doses, typically with 20 mcg given in the morning and 10 mcg given at nighttime). If administered more than once a day, adjust for an adequate diurnal rhythm of urine output. 90022 90031 90002 Because administration of desmopressin acetate can been associated with decreased responsiveness with prolonged use, consider increasing the dosage of desmopressin acetate nasal solution (nasal spray) if patients demonstrate decreased response over a long period of time.90009 90034 Switching Between Desmopressin Acetate Formulations 90035 90002 When switching from the desmopressin acetate injection to desmopressin acetate nasal solution (nasal spray), administer 10 times the amount of desmopressin acetate, rounding down to the nearest 10 mcg. 90009 90002 When switching from the desmopressin acetate tablets to desmopressin acetate nasal solution (nasal spray) individual dose titration is required because intranasal desmopressin is approximately 10 to 40 fold more potent than oral (tablet) desmopressin.90009 90012 Dosage Forms and Strengths 90013 90002 Desmopressin acetate nasal solution (nasal spray), 10 mcg / 0.1 mL per spray is available in a 5 mL bottle with spray pump delivering 50 sprays of 10 mcg. 90009 90012 Contraindications 90013 90002 Desmopressin acetate nasal solution (nasal spray) is contraindicated in patients with: 90009 90020 90021 Known hypersensitivity to desmopressin acetate or to any of the components of desmopressin acetate nasal solution (nasal spray). Severe allergic reactions and anaphylaxis have been reported [see Adverse Reactions (6)].90022 90021 Renal impairment defined as estimated creatinine clearance (CLcr) by Cockcroft-Gault equation less than 50 mL / min [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)]. 90022 90021 Hyponatremia or a history of hyponatremia [see Warnings and Precautions (5.1)]. 90022 90031 90012 Warnings and Precautions 90013 90034 Hyponatremia 90035 90002 Excessive fluid intake when urine output is limited by the antidiuretic effect of desmopressin may lead to water intoxication with hyponatremia.Cases of hyponatremia have been reported from postmarketing experience in patients treated with desmopressin acetate. Unless properly diagnosed and treated, hyponatremia can be fatal. 90009 90002 All patients receiving desmopressin acetate nasal solution (nasal spray) should be observed for the following signs or symptoms associated with hyponatremia: headache, nausea / vomiting, decreased serum sodium, weight gain, restlessness, fatigue, lethargy, disorientation, depressed reflexes, loss appetite, irritability, muscle weakness, muscle spasms or cramps and abnormal mental status such as hallucinations, decreased consciousness, and confusion.Severe symptoms due to an extreme decrease in serum sodium and plasma osmolality may include one or a combination of the following: seizure, coma, and / or respiratory arrest. 90009 90002 In order to decrease the risk of water intoxication with hyponatremia, fluid restriction is recommended. Careful fluid intake restriction is particularly important in pediatric and geriatric patients because these patients are at greater risk of developing hyponatremia [see Use in Specific Populations (8.4, 8.5)].More frequent monitoring of serum sodium levels is recommended in the following patients: those with conditions associated with fluid and electrolyte imbalance, such as cystic fibrosis, heart failure, renal disorders, habitual or psychogenic polydipsia or those taking concomitant drugs that may cause hyponatremia [see Drug Interactions (7.1)]. 90009 90002 Desmopressin acetate nasal solution (nasal spray) is not an indicated formulation for the treatment of primary nocturnal enuresis due to a higher risk of hyponatremia and hyponatremic convulsions with the use of the nasal spray formulation compared to desmopressin tablets seen in postmarketing reports [see Indications and Usage (1)].90009 90034 Altered Absorption in Patients with Nasal Mucosa Abnormalities 90035 90002 Chronic administration of desmopressin acetate nasal solution (nasal spray) may result in changes to nasal mucosa. Nasal mucosa abnormalities (such as scarring and edema) due to chronic administration, or due to other causes (nasal blockage, nasal mucosal atrophy, severe atrophic rhinitis, recent nasal surgery such as transsphenoidal hypophysectomy) may cause erratic, unreliable absorption. Avoid use of desmopressin acetate nasal solution (nasal spray) in such patients [see Indications and Usage (1)] and consider use of other formulations of desmopressin acetate given by other routes of administration.90009 90012 Adverse Reactions 90013 90002 The following serious reactions are described below and elsewhere in the labeling: 90009 90020 90021 Hyponatremia [see Warnings and Precautions (5.1)]. 90022 90021 Altered Absorption in Patients with Changes in Nasal Mucosa [see Warnings and Precautions (5.2)]. 90022 90031 90002 The following adverse reactions have been identified during post-approval use of desmopressin acetate. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure: 90009 90002 Increase in blood pressure, headache, nasal congestion, rhinitis, nosebleed, sore throat, cough, upper respiratory infections, nausea, flushing, and abdominal cramps.90009 90002 Water intoxication with hyponatremia 90009 90002 Hyponatremic convulsions associated with concomitant use of the following medications: oxybutinin and imipramine [see Drug Interactions (7.1)]. 90009 90002 Severe allergic reactions and anaphylaxis [see Contraindications (4)] 90009 90012 Drug Interactions 90013 90034 Other Drugs that may Increase Risk of Hyponatremia 90035 90002 The concomitant administration of desmopressin acetate nasal solution (nasal spray) with other drugs that may increase the risk of water intoxication with hyponatremia, (e.g., tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, NSAIDs, lamotrigine, oxybutynin and carbamazepine) requires more frequent serum sodium monitoring [see Warnings and Precautions (5.1) and Adverse Reactions (6)]. 90009 90034 Other Vasoconstrictors 90035 90002 Desmopressin acetate can elevate blood pressure. Use of large doses of desmopressin acetate nasal solution (nasal spray) with other vasocontrictors may require a reduction of the desmopressin acetate nasal solution (nasal spray) dosage [see Adverse Reactions (6)].90009 90012 USE IN SPECIFIC POPULATIONS 90013 90034 Pregnancy 90035 90002 Risk summary 90009 90002 Prolonged experience with desmopressin in pregnant women over several decades, based on the available published data and case reports, did not identify a drug associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes. In addition, in vitro studies with human placenta demonstrate poor placental transfer of desmopressin. No adverse developmental outcomes were observed in animal reproduction studies with administration of desmopressin during organogenesis to pregnant rats and rabbits at doses approximately <1 and 38 times, respectively, the maximum recommended human dose based on body surface area (mg / m2) (see Data ).90009 90002 The estimated background risk of major birth defects and miscarriage for the indicated population are unknown. In the US general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively. 90009 90002 Data 90009 90002 Animal Data 90009 90002 Desmopressin acetate at up to 50 ng / kg / day was given by subcutaneous injection to pregnant rats, from gestation day 1 to 20 during the period of early embryonic development and organogenesis without teratogenic effects.Desmopressin acetate at up to 10 mcg / kg / day was given to pregnant rabbits by subcutaneous injection from gestation day 6 to 18 during fetal organogenesis without teratogenic effects. These doses of desmopressin acetate represent approximately <1 times (rat) and 38 times (rabbit) the maximum recommended human dose based on body surface area (mg / m2). 90009 90034 Lactation 90035 90002 Risk Summary 90009 90002 Breastfeeding is not expected to result in clinically relevant exposure of the infant to desmopressin following maternal intranasal administration.Desmopressin is poorly transferred into human breastmilk at negligible amounts (see Data). There is no information on the effects of desmopressin on the breastfed infant or on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for desmopressin acetate nasal solution (nasal spray) and any potential adverse effects on the breastfed infant from desmopressin acetate nasal solution (nasal spray) or from the underlying maternal condition.90009 90002 Data 90009 90002 A trial was conducted in six healthy lactating women, at greater than 4 months postpartum, to evaluate intranasal administration of 300 mcg single dose of another desmopressin product (7.5 times the recommended adult dose of desmopressin acetate nasal solution (nasal spray)). Samples of maternal plasma and breastmilk were obtained at 0, 30, 60, 120, 240, 360 and 480 min after the drug administration. At 8 hours after dose intake, the levels in the milk ranged between 4.16 and 101 pg / ml, and the plasma levels ranged between 40 and 242 pg / ml. The total amount of desmopressin present in the milk over the 8 hours ranged between 491 pg and 16 ng, which corresponds to 0.0001 to 0.005% of the administered dose to the breastfeeding mother. 90009 90034 Pediatric Use 90035 90002 Desmopressin acetate nasal solution (nasal spray) is indicated as antidiuretic replacement therapy in the management of central diabetes insipidus in pediatric patients 4 years of age and older.Desmopressin acetate nasal solution (nasal spray) is not indicated in pediatric patients less than 4 years of age. 90009 90002 Use of desmopressin acetate nasal solution (nasal spray) in pediatric patients 4 years of age and older is supported by evidence from adults and pediatric patients with central diabetes insipidus. Use in pediatric patients requires careful fluid intake restriction to prevent possible water intoxication with hyponatremia [see Warnings and Precautions (5.1)]. 90009 90034 Geriatric Use 90035 90002 Clinical studies of desmopressin acetate nasal solution (nasal spray) did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.In general, dose selection for an elderly patient should be cautious, usually starting at a low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or drug therapy. 90009 90002 Because elderly patients are more likely to have renal impairment, care should be taken in dose selection, and monitoring renal function is recommended [see Contraindications (4), Use in Specific Populations (8.6)]. 90009 90002 Use of desmopressin acetate nasal solution (nasal spray) in geriatric patients requires careful fluid intake restriction to prevent possible water intoxication with hyponatremia [see Warnings and Precautions (5.1)]. 90009 90034 Renal Impairment 90035 90002 Desmopressin acetate is substantially excreted by the kidney, and the risk of adverse reactions may be greater in patients with renal impairment than patients with normal renal function. desmopressin acetate nasal solution (nasal spray) is contraindicated in patients with estimated CLcr by Cockcroft-Gault equation less than 50 mL / min [see Clinical Pharmacology (12.1, 12.3), Contraindications (4)]. 90009 90012 Overdosage 90013 90002 Signs of desmopressin acetate overdosage may include confusion, drowsiness, continuing headache, problems with passing urine, and rapid weight gain due to fluid retention [see Warnings and Precautions (5.1)]. In case of overdosage, reduce the dosage, decrease the frequency of administration, or discontinue desmopressin acetate nasal solution (nasal spray). There is no known specific antidote for desmopressin acetate. 90009 90012 Desmopressin Nasal Spray Description 90013 90002 Desmopressin acetate is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. It is chemically defined as follows: 90009 90002 Molecular weight: 1183.34 90009 90002 Molecular formula: C46H64N14O12S2 • C2h5O2 • 3h3O 90009 90190 90002 1- (3-mercaptopropionic acid) -8-D-arginine vasopressin monoacetate (salt) trihydrate. 90009 90002 Desmopressin acetate nasal solution (nasal spray) is provided as an aqueous solution for intranasal use. 90009 90002 Each mL contains: 90009 90197 90198 90198 90200 90201 90202 Desmopressin acetate, USP 90005 90204 90202 0.1 mg 90005 90204 90208 90201 90202 Sodium Chloride 90005 90204 90202 7.5 mg 90005 90204 90208 90201 90202 Citric acid monohydrate 90005 90204 90202 1.7 mg 90005 90204 90208 90201 90202 Disodium phosphate dihydrate 90005 90204 90202 3.0 mg 90005 90204 90208 90201 90202 Benzalkonium chloride solution (50%) 90005 90204 90202 0.2 mg 90005 90204 90208 90201 90202 Purified water to 1 mL 90005 90204 90245 90208 90247 90248 90002 The desmopressin acetate nasal solution (nasal spray) compression pump delivers 0.1 mL (10 mcg) of desmopressin acetate per spray.90009 90012 Desmopressin Nasal Spray - Clinical Pharmacology 90013 90034 Mechanism of Action 90035 90002 The antidiuretic effects of desmopressin are mediated by stimulation of vasopressin 2 (V2) receptors, thereby increasing water re-absorption in the kidney, and hence reducing urine production. Desmopressin is a replacement hormone for antidiuretic hormone in the treatment of central diabetes insipidus. The change in structure of arginine vasopressin to desmopressin acetate resulted in a decreased vasopressor action and decreased actions on visceral smooth muscle relative to the enhanced antidiuretic activity, so that clinically effective antidiuretic doses were usually below threshold levels for effects on vascular or visceral smooth muscle.90009 90034 Pharmacodynamics 90035 90002 The use of desmopressin acetate nasal solution (nasal spray) in patients with central diabetes insipidus reduces urinary output, increases urine osmolality, and decreases plasma osmolality. 90009 90034 Pharmacokinetics 90035 90002 Absorption 90009 90002 Desmopressin acetate is absorbed through the nasal mucosa. 90009 90002 Elimination 90009 90002 Desmopressin acetate exhibits a biphasic elimination profile, with half-lives of 7.8 and 75.5 minutes for the initial and terminal phases, respectively. 90009 90002 Specific Populations 90009 90002 Renal Impairment 90009 90002 Desmopressin acetate is mainly excreted in the urine. A pharmacokinetic study was conducted in subjects with normal renal function and patients with mild, moderate, and severe renal impairment (n = 24, 6 subjects each group) with a single 2 mcg dose of desmopressin acetate injection (this results in approximately 20 times the exposure of 10 mcg of desmopressin acetate nasal solution (nasal spray)).The terminal half-life was 2.8 hours in subjects with normal renal function, 4.0 hours in mild renal impairment, 6.6 hours in moderate renal impairment and 8.7 hours in severe renal impairment. In patients with mild, moderate and severe renal impairment, mean desmopressin exposure was 1.5 fold, 2.4 fold and 3.6 fold higher, respectively compared to that of subjects with normal renal function [see Contraindications (4), Use in Specific Populations (8.6)] . 90009 90012 Nonclinical Toxicology 90013 90034 Carcinogenesis, Mutagenesis, Impairment of Fertility 90035 90002 Studies with desmopressin acetate have not been performed to evaluate carcinogenic potential, mutagenic potential, or effects on fertility.90009 90012 How Supplied / Storage and Handling 90013 90034 How Supplied 90035 90002 Desmopressin acetate nasal solution (nasal spray), 10 mcg / 0.1 mL per spray is available in a 5 mL bottle with the spray pump delivering 50 sprays of 10 mcg. 90009 90002 NDC 70771-1314-1 90009 90034 Storage and Handling 90035 90002 Store at 20 ° C to 25 ° C (68 ° F to 77 ° F) [see USP Controlled Room Temperature]. STORE BOTTLE IN UPRIGHT POSITION. 90009 90012 Patient Counseling Information 90013 90002 Advise the patient to read the FDA-approved patient labeling (Patient Information and Instructions for Use) 90009 90002 Administration 90009 90020 90021 Inform caregivers for pediatric patients that administration should be supervised to ensure the patient receives the prescribed dose.90022 90021 Inform patients that the pump must be primed prior to first use and again if not used for greater than one week. Inform patients that the desmopressin acetate nasal solution (nasal spray) bottle delivers 50 sprays of 10 mcg each following the initial 4 priming pumps. 90022 90021 Inform patients to discard any solution remaining after 50 sprays since the amount delivered thereafter may be substantially less than 10 mcg of drug. 90022 90031 90002 Monitoring 90009 90020 90021 Educate patients about the signs and symptoms of hyponatremia and advise them to contact a healthcare provider if such symptoms occur.90022 90021 Discuss downward adjustment of fluid intake and monitoring of urine output with patients. 90022 90031 90002 Manufactured by: 90009 90002 Cadila Healthcare Ltd. 90009 90002 Ahmedabad, India. 90009 90002 Rev .: 12/19 90009 90012 SPL PATIENT PACKAGE INSERT 90013 90197 90198 90200 90201 90202 Patient Information 90005 Desmopressin Acetate Nasal Solution (des "moe pres 'in as' e tate) 90005 (Nasal Spray), 10 mcg per 0.1 mL 90005 for Intranasal Use Only 90005 90204 90208 90201 90202 What is desmopressin acetate nasal solution (nasal spray)? 90005 Desmopressin acetate nasal solution (nasal spray) is a prescription medicine called a vasopressin analog used as an antidiuretic replacement to manage central diabetes insipidus.90005 90020 90021 Desmopressin acetate nasal solution (nasal spray) is not effective in the treatment of nephrogenic diabetes insipidus. 90022 90021 Desmopressin acetate nasal solution (nasal spray) should not be used in people with nasal problems that may keep them from using a nasal spray. 90022 90031 90204 90208 90201 90202 Who should not use desmopressin acetate nasal solution (nasal spray)? 90005 Do not use desmopressin acetate nasal solution (nasal spray) if you: 90005 90020 90021 are allergic to desmopressin acetate nasal solution (nasal spray) or any of the ingredients in desmopressin acetate nasal solution (nasal spray).Some people have had severe allergic reactions while taking desmopressin acetate nasal solution (nasal spray). See the end of this Patient Information for a complete list of ingredients in desmopressin acetate nasal solution (nasal spray). 90022 90021 have kidney problems 90022 90021 have or have had low levels of sodium in your blood (hyponatremia) 90022 90031 90204 90208 90201 90202 What should I tell my healthcare provider before using desmopressin acetate nasal solution (nasal spray)? 90005 Before using desmopressin acetate nasal solution (nasal spray), tell your healthcare provider about all your medical conditions including if you: 90005 90020 90021 have or have had nasal sores, nasal surgery, nasal injury, or have problems such as a stuffy nose or trouble 90022 90021 breathing through your nose.90022 90021 have or have had any heart, blood circulation, or blood pressure problems 90022 90021 have a condition that causes fluid or water imbalance problems such as cystic fibrosis, or heart failure. 90022 90021 have or have had a condition that causes you to be very thirsty 90022 90021 are pregnant or plan to become pregnant. It is not known if desmopressin acetate nasal solution (nasal spray) will harm your unborn baby. 90022 90021 are breastfeeding or plan to breastfeed. It is not known if desmopressin acetate nasal solution (nasal spray) passes into your breast milk.You and your healthcare provider should decide if you will use desmopressin acetate nasal solution (nasal spray). 90022 90031 Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. 90005 90204 90208 90201 90202 How should I use desmopressin acetate nasal solution (nasal spray)? 90005 90020 90021 Read the Instructions for Use that comes with your desmopressin acetate nasal solution (nasal spray).90022 90021 Use desmopressin acetate nasal solution (nasal spray) exactly as your healthcare provider tells you to use it. 90022 90021 Your healthcare provider may change your dose of desmopressin acetate nasal solution (nasal spray) if needed. 90022 90031 90204 90208 90201 90202 What are the possible side effects of desmopressin acetate nasal solution (nasal spray)? 90005 Desmopressin acetate nasal solution (nasal spray) may cause serious side effects including: 90005 90020 90021 low levels of sodium in the blood (hyponatremia).People using desmopressin acetate nasal solution (nasal spray) are at risk for low sodium levels in the blood, water intoxication, and fluid overload. Follow your healthcare provider's instructions on limiting the amount of fluid you can drink when using desmopressin acetate nasal solution (nasal spray). 90022 90031 ○ Do not drink more than you need to satisfy your thirst. You can have serious side effects such as seizures, coma, and death from drinking too much fluid. 90005 ○ Children and the elderly are at higher risk for these problems and should follow their healthcare provider's limits on drinking fluids.90005 ○ Call your healthcare provider right away if you have any of the following symptoms while using desmopressin acetate nasal solution (nasal spray). They may mean that your blood sodium level is too low. 90005 headache 90005 ▪ restlessness 90005 ▪ disorientation 90005 ▪ feeling irritable 90005 ▪ hallucinations 90005 ▪ nausea, vomiting 90005 ▪ tiredness 90005 ▪ loss of appetite 90005 ▪ feeling weak 90005 ▪ confusion 90005 ▪ weight gain 90005 ▪ sleepiness 90005 ▪ muscle cramps 90005 90020 90021 nasal scarring or swelling.Some people using desmopressin acetate nasal solution (nasal spray) for long periods of time may have nasal problems such as scarring or swelling. This may affect how well desmopressin acetate nasal solution (nasal spray) works for you. 90022 90031 The most common side effects of desmopressin acetate nasal solution (nasal spray) include: headache, stuffy nose, runny nose, nosebleed, sore throat, cough, upper respiratory infections, nausea, flushing, and stomach cramps. 90005 Call your doctor for medical advice about side effects.You may report side effects to FDA at 1-800-FDA-1088. 90005 90204 90208 90201 90202 General information about the safe and effective use of desmopressin acetate nasal solution (nasal spray). 90005 Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use desmopressin acetate nasal solution (nasal spray) for a condition for which it was not prescribed. Do not give desmopressin acetate nasal solution (nasal spray) to other people, even if they have the same symptoms that you have.It may harm them. You can ask your healthcare provider or pharmacist for information about desmopressin acetate nasal solution (nasal spray) that is written for health professionals. For more information call 1-877-993-8779 90005 90204 90208 90201 90202 What are the ingredients in desmopressin acetate nasal solution (nasal spray)? 90005 Active ingredient: desmopressin acetate, USP 90005 Inactive ingredients: benzalkonium chloride solution (50%), sodium chloride, citric acid monohydrate, disodium phosphate dihydrate, purified water 90005 90204 90208 90201 90202 This Patient Information has been approved by the Food and Drug Administration 90005 90204 90208 90201 90202 Manufactured by: 90005 Cadila Healthcare Ltd.90005 Ahmedabad, India. 90002 Distributed by: 90005 Zydus Pharmaceuticals (USA) Inc. 90005 Pennington, NJ 08534 90005 Rev .: 12/19 90005 90009 90204 90208 90247 90248 90012 SPL UNCLASSIFIED 90013 90002 INSTRUCTIONS FOR USE 90009 90002 Desmopressin Acetate Nasal Solution (Nasal Spray), 10 mcg per 0.1 mL 90009 90002 For Intranasal Use Only 90009 90002 Read these instructions before using desmopressin acetate nasal solution (nasal spray), and each time you get a refill. There may be new information.This information does not take the place of talking to your healthcare provider about your medical condition or treatment. 90009 90002 Children should be helped by an adult when using desmopressin acetate nasal solution (nasal spray), to make sure the right amount of medicine is used. 90009 90002 The parts of your desmopressin acetate nasal solution (nasal spray) Nasal Spray pump (see Figure A): 90009 90190 90002 Priming your desmopressin acetate nasal solution (nasal spray): 90009 90002 Your desmopressin acetate nasal solution (nasal spray) Nasal Spray pump must be primed before you use it for the first time.90009 90020 90021 Remove the protective cap (see Figure B). 90022 90031 90190 90020 90021 Press down on the shoulders at the top of your desmopressin acetate nasal solution nasal spray pump 4 times. Hold the spray tip away from your face and eyes (see Figure C). 90022 90031 90190 90020 90021 After your desmopressin Acetate Nasal Solution (nasal spray) Nasal Spray pump is primed, it will spray 10 micrograms (1 dose) of medicine each time it is pressed. 90022 90031 90002 Using your desmopressin acetate nasal solution (nasal spray): 90009 90002 Step 1.Remove the protective cap. 90009 90002 Step 2. To make sure you get the right dose of medicine tilt your desmopressin acetate nasal solution nasal spray pump so the dip tube inside the bottle draws the medicine up from the deepest part of the medicine inside the bottle (see Figures D and E ). 90009 90190 90002 Step 3. Put the spray nozzle tip of your desmopressin acetate nasal solution (nasal spray) into your nostril and press the spray pump 1 time for 1 dose. (See Figure F). If 2 doses are prescribed, spray each nostril 1 time.90009 90190 90002 Step 4. Put the protective cap back on the spray nozzle tip when you finish using your desmopressin acetate nasal solution (nasal spray). 90009 90002 Keeping track of your Nasal Sprays: 90009 90020 90021 Use the check-off chart to help you keep track of your desmopressin acetate nasal solution (nasal spray) used (see Figure G). 90022 90031 90190 90020 90021 Keep this chart with your desmopressin acetate nasal solution (nasal spray) or put it someplace where you can easily get it.90022 90021 Check off number 1 on the chart with your first dose of desmopressin acetate nasal solution (nasal spray). Check off the numbers after each use of your desmopressin acetate nasal solution (nasal spray). If your healthcare provider prescribed a 2-spray dose, then 2 numbers should be checked off. 90022 90021 Your desmopressin acetate nasal solution (nasal spray) holds 50 sprays with the right amount of medicine in each spray. 90022 90021 If any medicine is left in your desmopressin acetate nasal solution (nasal spray) after 50 sprays, do not use it.You may not get the right amount of medicine. 90022 90021 Throw away your desmopressin acetate nasal solution (nasal spray) after 50 sprays. 90022 90021 Do not count the priming sprays. Your desmopressin acetate nasal solution (nasal spray) has been filled with extra medicine for your priming sprays. 90022 90021 Do not try to remove any medicine from your desmopressin acetate nasal solution Nasal Spray pump and place it in another bottle. 90022 90031 90002 How should I store desmopressin acetate nasal solution (nasal spray)? 90009 90020 90021 Store desmopressin acetate nasal solution (nasal spray) at room temperature between 68ºF to 77ºF (20ºC to 25ºC).90022 90021 Store desmopressin acetate nasal solution (nasal spray) standing upright. 90022 90031 90002 This Instructions for Use has been approved by the U.S. Food and Drug Administration. 90009 90002 Manufactured by: 90009 90002 Cadila Healthcare Ltd. 90009 90002 Ahmedabad, India. 90009 90002 Rev .: 12/19 90009 90012 PACKAGE LABEL.PRINCIPAL DISPLAY PANEL 90013 90002 NDC 70771-1314-1 90009 90002 Desmopressin Acetate Nasal Solution (Nasal Spray), 10 mcg / 0.1 mL per spray 90009 90002 5 mL 90009 90002 Rx only 90009 90190 90197 90200 90201 90202 90565 DESMOPRESSIN ACETATE 90566 90005 desmopressin acetate spray 90204 90208 90201 90202 90197 90201 90574 Product Information 90204 90208 90201 90202 Product Type 90204 90202 HUMAN PRESCRIPTION DRUG LABEL 90204 90202 Item Code (Source) 90204 90202 NDC: 70771-1314 90204 90208 90201 90202 Route of Administration 90204 90202 NASAL 90204 90202 DEA Schedule 90204 90202 90204 90208 90248 90204 90208 90201 90202 90197 90201 90604 Active Ingredient / Active Moiety 90204 90208 90201 90202 Ingredient Name 90204 90202 Basis of Strength 90204 90202 Strength 90204 90208 90201 90202 90565 DESMOPRESSIN ACETATE 90566 (DESMOPRESSIN) 90204 90202 DESMOPRESSIN ACETATE 90204 90202 0.1 mg in 1 mL 90204 90208 90248 90204 90208 90201 90202 90197 90201 90632 Inactive Ingredients 90204 90208 90201 90202 Ingredient Name 90204 90202 Strength 90204 90208 90201 90202 90565 SODIUM CHLORIDE 90566 90204 90202 90204 90208 90201 90202 90565 CITRIC ACID MONOHYDRATE 90566 90204 90202 90204 90208 90201 90202 90565 SODIUM PHOSPHATE, DIBASIC, DIHYDRATE 90566 90204 90202 90204 90208 90201 90202 90565 BENZALKONIUM CHLORIDE 90566 90204 90202 90204 90208 90201 90202 90565 WATER 90566 90204 90202 90204 90208 90248 90204 90208 90201 90245 90208 90201 90202 90197 90201 90574 Packaging 90204 90208 90201 90202 # 90204 90202 Item Code 90204 90202 Package Description 90204 90208 90201 90202 90565 1 90566 90204 90202 NDC: 70771-1314-1 90204 90202 5 mL in 1 BOTTLE, SPRAY 90204 90208 90248 90204 90208 90201 90245 90208 90201 90202 90197 90201 90574 Marketing Information 90204 90208 90201 90202 Marketing Category 90204 90202 Application Number or Monograph Citation 90204 90202 Marketing Start Date 90204 90202 Marketing End Date 90204 90208 90201 90202 ANDA 90204 90202 ANDA091345 90204 90202 02/01/2018 90204 90245 90208 90248 90204 90208 90247 90248 90197 90201 90574 Labeler - Cadila Healthcare Limited (918596198) 90204 90208 90248 90197 90201 90574 Registrant - Cadila Healthcare Limited (918596198) 90204 90208 90248 90197 90201 90574 Establishment 90204 90208 90201 90202 Name 90204 90202 Address 90204 90202 ID / FEI 90204 90202 Operations 90204 90208 90201 90202 Cadila Healthcare Limited 90204 90245 90202 918596198 90204 90202 ANALYSIS (70771-1314), MANUFACTURE (70771-1314) 90204 90208 90248 90002 Cadila Healthcare Limited 90009 90034 Related questions 90035 90002 Medical Disclaimer 90009 .